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Immunobiology of Nitric Oxide and Regulation of Inducible Nitric Oxide Synthase

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Macrophages

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 62))

Abstract

Nitric oxide (NO) is a bioactive gas that has multiple roles in innate and adaptive immune responses. In macrophages, nitric oxide is produced by inducible nitric oxide synthase upon microbial and cytokine stimulation. It is needed for host defense against pathogens and for immune regulation. This review will summarize the role of NO and iNOS in inflammatory and immune responses and will discuss the regulatory mechanisms that control inducible nitric oxide synthase expression and activity.

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Authors and Affiliations

  1. Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada

    Martin Lee, Kevin Rey, Katrina Besler, Christine Wang & Jonathan Choy

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  1. Martin Lee
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  2. Kevin Rey
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  3. Katrina Besler
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  4. Christine Wang
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  5. Jonathan Choy
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Correspondence to Jonathan Choy .

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  1. Department of Surgery, The Houston Methodist Hospital, Houston, Texas, USA

    Malgorzata Kloc

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Lee, M., Rey, K., Besler, K., Wang, C., Choy, J. (2017). Immunobiology of Nitric Oxide and Regulation of Inducible Nitric Oxide Synthase. In: Kloc, M. (eds) Macrophages. Results and Problems in Cell Differentiation, vol 62. Springer, Cham. https://doi.org/10.1007/978-3-319-54090-0_8

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